2016 Cancer Projects

Cancer Projects

Type of Cancer

Anal Neuroblastoma
Breast  Non site-specific
Cervical Oesophageal
Childhood Ovarian
Colorectal Prostate
Gastrointestinal Salivary gland
Head and neck  Sarcoma
Liver Skin
Lung Spinal
Lymphoma Testicular
Myeloma Thyroid


  UCT Investigator
Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus

Dhiren Govender


UCT Investigator

Identification of novel drug targets for treating breast cancer Sharon Prince
Pathways to breast cancer presentation Jennifer Moodley
The genetics of anthracycline-induced cardiotoxicity in breast cancer patients Horacia Naidoo
Triple negative breast cancer : tumour-initiating cells and tailoring therapy Horacia Naidoo
A correlation between shoulder pain and dysfunction and inflammatory cytokine genotyping in breast cancer patients Delva Shamley
Prevalence of upper limb morbidity following adjuvant therapy in breast cancer survivors in SA Delva Shamley
Pain lateralisation in breast cancer patients: a fMRI and genotyping study Delva Shamley
Opioid prescription post-surgery for breast cancer and the development of chronic pain Delva Shamley
Development and implementation of an integrated  lymphoedema management pathway following treatment for breast cancer Delva Shamley
A randomised, Double blind, Phase 3 study evaluating the efficacy and safety of ABP 980 compared with Trastuzumab in subjects with HER2 positive early breast cancer  David Anderson
Testing a dual-modality system that combines full-field digital mammography and automated breast ultrasound for the detection of breast cancer Tania Douglas / Kit Vaughan
Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa Jennifer Moodley
  UCT Investigator
Preventing cervical cancer: Using mobile technology to improve management and follow-up of clients

Jennifer Moodley

Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa Jennifer Moodley
Audit of indications for and outcomes of cone biopsies performed at GSH colposcopy clinic  Lynette Denny
Therapeutic vaccine against HPV types 16 and 18 Lynette Denny
Improving the specificity of HPV Screen-and-Treat in South Africa Lynette Denny
The cellular mechanisms induced by photodynamic therapy in carcinomas of the skin and cervix Lester Davids
Identification and characterization of HPV entry receptors as potential drug targets Georgia Schafer
Investigation of the impact of the vaginal microbiota on human papillomavirus infections Anna-Lise Williamson
  UCT Investigator
Dysregulation of CT antigen expression in HNPCC and microbially-associated colorectal cancers Jonathan Blackburn
Pharmacoproteomic and pharmacogenomic profiling of stage II and III primary colorectal carcinoma tissue
Cancer pathways analysis in individuals with Lynch Syndrome Raj Ramesar
A genetic registry for colorectal cancers Raj Ramesar
  UCT Investigator
Characterization of gastrointestinal stromal tumour mutations in a South African cohort Barbara Robertson
MK-3475-062: A randomised active-controlled, partially blinded, biomarker select, phase III clinical trial of pembrolizumab as monotherapy and in combination with cisplatin + 5-fluorourcil versus placebo + cisplatin and 5-fluorouracil as first-line treatment in subjects with advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma Barbara Robertson
MK-3475-061-00: A phase III, randomized open-label clinical trial of pembrolizumab (MK-3475) versus paclitaxel in subjects with recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma who progressed after first-line therapy with platinum and fluoropyrimidine Barbara Robertson
A biochemical analysis of mucus and mucins in pseudomyxoma peritonei (cancer of the appendix) Anwar Mall
No projects currently  
  UCT Investigator
Do Hepatitis B and HIV interact in the aetiology of hepatocellular carcinoma Michael Kew
HIV-associated hepatocellular carcinoma – prevalence, presentation, survival and risks Barbara Robertson
  UCT Investigator
A Randomised, Open Label, Phase III Study of Overall Survival Comparing Pembrolizumab (MK-3475) versus Platinum Based Chemotherapy in Treatment Naïve Subjects with PD-L1 Positive advanced or Metastatic Non-Small Cell Lung Cancer Lucinda Shepherd
  UCT Investigator
Investigation of the molecular mechanisms of HIV-induced Burkitt’s lymphoma development Shaheen Mowla
Expression and function of miRNA in HIV-associated lymphomas
A randomized controlled double blind phase III trial to compare the efficacy, safety and pharmacokinetics of GP2013 plus cyclophosphamide, vincristine, prednisone, followed by GP2013 or MabThera Contact UCTtenance therapy in patients with previously untreated, advanced stage follicular lymphoma Zainab Mohamed
Biomarker identification in HIV- and non HIV related diffuse large B cell lymphomas Richard Naidoo
  UCT Investigator
Cancer testis antigens in multiple myeloma Karen Shires
Mage antigen expression: A tool for malignant cell identification, disease monitoring and determining diseases mechanisms
  UCT Investigator
Photodynamic therapy as a potential treatment modality in neuroblastoma cancers Lester Davids
  UCT Investigator
Hospital based oesophageal cancer registry Iqbal Parker
Molecular biology and molecular markers of oesphageal cancer Iqbal Parker
Patient and tumour characteristics as prognostic factors in oesophageal cancer: survival analysis Collet Dandara
Whole genome sequence analysis of African oesophageal squamous cell carcinoma  Iqbal Parker
No projects currently  
  UCT Investigator
The immuno expression of p53-cofactor JMY in prostatic adeno-carcinoma & its effects on cells cycle and Cell Adhesion molecules Dhiren Govender
  UCT Investigator
Salivary gland rescue to overcome radiotherapy-induced xerostomia Alistair Hunter
  UCT Investigator
Overexpression of the t-box transcription factor, tbx3, as an early marker of sarcomas     Sharon Prince 
A randomized controlled study of yondelis (trabectedin) or dacarbazine for the treatment of advanced liposarcoma or leiomyosarcoma Jeanette Parkes
Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review Zainab Mohamed
The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa Georgia Shafer
  UCT Investigator
The use of hypericin-induced photodynamic therapy (PDT) as a potential novel adjuvant  cancer therapy Lester Davids
The cellular mechanisms induced by PDT in carcinomas of the skin and cervix 
Proteomic studies on patient responses to vaccination and chemotherapy/ radiotherapy in melanoma Jonathan Blackburn
The use of hypericin-induced photodynamic therapy (PDT) as a potential novel adjuvant  cancer therapy Lester Davids
An investigation into the sensitizing effect of photodynamic therapy in melanoma chemotherapy resistant populations Lester Davids
Investigating Cancer-associated fibroblasts in the Melanoma tumor microenvironment Lester Davids
Identification of novel drugs and drug targets for treating melanoma Sharon Prince
  UCT Investigator
Review of surgical management primary spine tumours in adult and paediatric population Robert Dunn
  UCT Investigator
International Ovarian & Testicular Stromal Tumour Registry Alan Davidson    
  UCT Investigator
Genetics of thyroid carcinoma to develop cost-effective management Ian Ross / Collet Dandara
  UCT Investigator
B-cell lymphoma at the Red Cross Children’s Hospital in the HIV era Alan Davidson
HIV and childhood malignancy in South Africa
Prevalence, incidence and risk factors, survival and prognosis for HIV-infected children developing cancer
Factors Associated with Childhood Tumours (FACT) study
Childhood histiocytosis in South African paediatric oncology units
Low grade gliomas treated at the UCT Academic Hospital Complex 2001-2013
Paediatric brain tumours in South Africa Anthony Figaji
Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG) Marc Hendricks
Clinical outcome of children with Hodgkin Lymphoma after chemotherapy alone – the Red Cross Children’s Hospital experience Alan Davidson
National incidence and treatment outcomes ofpaediatric acute lymphoblastic leukaemia in South Africa over a five year period
Race as a prognostic determinant in children with acute lymphoblastic leukaemia    
The results of acute myeloid leukaemia treated with RCCH Rx2071 (adapted from the MRC AML 15 protocol)    
International ovarian & testicular stromal tumour registry
  UCT Investigator
Mitochondrial flux in cell death processes induced by cancer therapy Andre Hendrikse
The role of the DNA-editing enzyme, activation-induced cytidine deaminase (AID), in cancer Shaheen Mowla
The effect of drug or carcinogen treatment on differential expression of drug metabolism genes in cancer cells Collet Dandara
Opposing roles for the t-box transcription factor, tbx3, in cancer: oncoprotein vs tumour suppressor Sharon Prince
Development of novel metallodrugs based on platinum group metals for treating cancer Sharon Prince
Investigating the role of genetic variation in OTOS in response to cisplatin induced ototoxicity in South African Cancer patients Raj Ramesar
The genetics of anthracycline-induced cardiotoxicity in cancer patients Raj Ramesar
Radiation-induced autophagy in cancer cells in vitro Alistair Hunter
Radiation-induced motility of cancer cells in vitro Alistair Hunter
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death Alistair Hunter / Michelle Parker
Development of an ajoene-based anti-cancer therapeutic Catherine Kaschula
Studies into the anti-inflammatory activity of natural products in cancer prevention Catherine Kaschula
A bibliometric analysis of cancer research in South Africa

Jennifer Moodley

Chloroquine as a modulator of autophagy and radiation response Alistair Hunter / Andre Hendrikse
Prevention of chemotherapy induced alopecia with scalp cooling – does hair curl influence outcome? Nonhlanhla Khumalo