2019 Cancer Projects

Cancer Projects

 

Bladder cancer

  1. Does enhanced recovery after surgery for radical cystectomy improve outcomes?

Contact UCT investigator: Justin Howlett

Email address: howlettjustin@gmail.com

 

Bone cancer

  1. Medical image synthesis - Development and validation of MRI-based synthetic CT: applications in treating bone pathologies

Contact UCT investigator: Tinashe Mutsvangwa

Email address: tinashe.mutsvangwa@uct.ac.za

 

Brain cancer

  1. Paediatric brain tumours in South Africa

Contact UCT investigator: Anthony Figaji

Email address: anthony.figaji@uct.ac.za

 

  1. Medulloblastoma

Contact UCT investigator: Jeanette Parkes

Email address: jeanette.parkes@uct.ac.za

 

  1. Development of SNAP-tag and CLIP-tag based antibody fusion proteins targeting Glioblastoma

Contact UCT investigator: Sanele Cingo /Stefan Barth

Email address: cngsip004@myuct.ac.za  / stefan.barth@uct.ac.za

 

  1. Investigating the anti-cancer activity of novel phenothiazines in glioblastoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma

Contact UCT investigator: Sharon Prince/Anwar Jardine

Email address: sharon.prince@uct.ac.za / anwar.jardine@uct.ac.za

 

Breast cancer

  1. Normalization of tumour metabolism to modulate radiation response

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

  1. Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death

Contact UCT investigator: Alistair Hunter / Michelle Parker

Email address: alistair.hunter@uct.ac.za / michelle.parker@uct.ac.za

 

  1. A correlation between shoulder pain and dysfunction and inflammatory cytokine genotyping in breast cancer patients

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Development and implementation of an integrated  lymphoedema and upper limb rehabilitation management pathway following treatment for breast cancer

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Opioid prescription post-surgery for breast cancer and the development of chronic pain

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Pain lateralisation in breast cancer patients: a fMRI and genotyping study

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Prevalence of upper limb morbidity following adjuvant therapy in breast cancer survivors in SA

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Extended Cost Effectiveness of Interventions for Early Detection & Treatment of Breast Cancer: A Case Study of South Africa and Uganda

Contact UCT investigator: Edina Sinanovic

Email address: edina.sinanovic@uct.ac.za

 

  1. Contraceptive needs and fertility intentions of women with breast cancer in Cape Town

Contact UCT investigator: Jane Harries

Email address: jane.harries@uct.ac.za

 

  1. Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. Primary health care providers knowledge and management of symptoms suggestive of breast cancer

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. Clinical Trial of the Aceso Dual-Modality System for the Early Detection of Breast Cancer: A Joint Project Between Number Two Military Hospital In Wynberg and CapeRay Medical (Pty) Ltd

Contact UCT investigator: Kamila Padia / Kit Vaughan

Email address: kamila.padia@uct.ac.za / Kit.vaughan@uct.ac.za

 

  1. Human Dendritic Cell Vaccination (DCV) Against Breast cancer: A Single Blind randomized trial

Contact UCT investigator: Keertan Dheda / David Anderson

Email address: keertan.dheda@uct.ac.za / david.anderson@uct.ac.za

 

  1. Rational Design of Glycoenzyme inhibitors and their Targeted Delivery for Blocking Apoptotic Metastatic Pathways in Breast Cancer Tumours

Contact UCT investigator: Kevin Naidoo

Email address: kevin.naidoo@uct.ac.za

 

  1. A Proof of Principle Application of the GlycoEnzyme Gene Biomarker for Early Detection of Breast Cancer in a South African Population

Contact UCT investigator: Kevin Naidoo

Email address: kevin.naidoo@uct.ac.za

 

  1. An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. Radio Guided Occult Lesion Localisation as a diagnostic and therapeutic procedure: Clinical review at a single South African institution

Contact UCT investigator: Lydia Cairncross

Email address: lydia.cairncross@uct.ac.za

 

  1. Antibody engineering to enhance antigen affinity, internalization and pharmacokinetics of tumor-targeting fusion proteins

Contact UCT investigator: Maryam Karaan /Stefan Barth

Email address:  krnmar009@myuct.ac.za  / stefan.barth@uct.ac.za

 

  1. Establishment of technology platforms in support of future precision medicine applications in South Africa

Contact UCT investigator: Musa Mhlanga / Stefan Barth

Email address: musa.mhlanga@uct.ac.za / stefan.barth@uct.ac.za

 

  1. Development of SNAP tag-based antibody fusion proteins for multiplex Immunofluorescence (mIF) and immunotherapy of Triple Negative Breast Cancer (TNBC)

Contact UCT investigator: Natasha Hardcastle /Stefan Barth

Email address: natasha.hardcastle@uct.ac.za / stefan.barth@uct.ac.za

 

  1. Development of CSPG4-targeting MAP tau-based human cytolytic fusion proteins and novel auristatin F-containing immunoconjugates for the treatment of triple-negative breast cancer

Contact UCT investigator: Neelakshi Mungra /Stefan Barth

Email address: mngnee002@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. Lynch Syndrome

Contact UCT investigator: Paul Goldberg

Email address: paul.goldberg@uct.ac.za

 

  1. Development of CSPG4-targeting human cytolytic fusion proteins based on Angiogenin variants for the treatment of triple-negative breast cancer

Contact UCT investigator: Sandra Jordaan/Stefan Barth

Email address: sandrajordaanibms@gmail.com / stefan.barth@uct.ac.za

 

  1. Identification of novel drug targets for treating breast cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. The anti-cancer activity of extracts derived from millets and kraalbos

Contact UCT investigator: Sharon Prince / Anwar Jardine / Suparna Chakraborty

Email address: sharon.prince@uct.ac.za / anwar.jardine@uct.ac.za / suparna.chakraborty@uct.ac.za

 

  1. Development of novel immunodiagnostic techniques using SNAP-tag based antibody fusion proteins as imaging tools for the validation of Triple Negative Breast Cancer (TNBC).

Contact UCT investigator: Siyabulela Magugu /Stefan Barth

Email address: mggsiy003@myuct.ac.za  / stefan.barth@uct.ac.za

 

  1. A randomized open label phase III study of single agent pembrolizumab versus single agent chemotherapy per physician’s choice for metastatic triple negative breast cancer (mTNBC)

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

  1. The role and regulation of TBX2/TBX3 in breast cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

  1. The c-Myc/Akt/TBX3/Hsc70/nucleolin signaling axis in breast cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

  1. Chromomycin A5 targets the oncogenic TBX2 as a new strategy to treat breast cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

Childhood cancer

  1. B-cell lymphoma at the Red Cross Children’s Hospital in the HIV era

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. Factors Associated with Childhood Tumours (FACT) study

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. Low grade gliomas treated at the UCT Academic Hospital Complex 2001-2013

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. National incidence and treatment outcomes of paediatric acute lymphoblastic leukaemia in South Africa over a five year period

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. Prevalence, incidence and risk factors, survival and prognosis for HIV-infected children developing cancer

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. Race as a prognostic determinant in children with acute lymphoblastic leukaemia    

Contact UCT investigator: Alan Davidson

Email address: alan.davidson@uct.ac.za

 

  1. Adapted Treatment Regimens for Hepatoblastoma and AML

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. HIV and childhood malignancy in South Africa

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Childhood histiocytosis in South African paediatric oncology units

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Clinical outcome of children with Hodgkin Lymphoma after chemotherapy alone – the Red Cross Children’s Hospital experience

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Epidemiology of paediatric Cancer in the RCCH/GSH/UCT complex

Contact: Alan Davidson / Jeannette Parkes / Komala Pillay

Email address: alan.davidson@uct.ac.za / jeannette.parkes@uct.ac.za / komala.pillay@uct.ac.za

 

  1. Paediatric brain tumours in South Africa

Contact UCT investigator: Anthony Figaji

Email address: anthony.figaji@uct.ac.za

 

  1. Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG)

Contact UCT investigator: Marc Hendricks

Email address: marc.hendricks@uct.ac.za

 

  1. Use of palliative chemotherapy in South Africa: National survey of paediatric oncologists and experience in a single unit

Contact UCT investigator: Michelle Meiring

Email address: michelle.meiring@uct.ac.za

 

  1. Palliative & supportive care needs of children with cancer from the family’s viewpoint: Can we do better?

Contact UCT investigator: Michelle Meiring

Email address: michelle.meiring@uct.ac.za

 

Colorectal cancer

  1. Dysregulation of CT antigen expression in HNPCC and microbially-associated colorectal cancers

Contact UCT investigator: Jonathan Blackburn

Email address: jonathan.blackburn@uct.ac.za

 

  1. Pharmacoproteomic and pharmacogenomic profiling of stage II and III primary colorectal carcinoma tissue

Contact UCT investigator: Jonathan Blackburn

Email address: jonathan.blackburn@uct.ac.za

 

  1. Worm power: Can helminths modify the development of colorectal cancer?

Contact UCT investigator: Katherine Smith

Email address: katie.smith@uct.ac.za

 

  1. Establishment of technology platforms in support of future precision medicine applications in South Africa

Contact UCT investigator: Musa Mhlanga / Stefan Barth

Email address: musa.mhlanga@uct.ac.za / stefan.barth@uct.ac.za

 

  1. Lynch Syndrome

Contact UCT investigator: Paul Goldberg

Email address: paul.goldberg@uct.ac.za

 

  1. A genetic registry for colorectal cancers

Contact UCT investigator: Raj Ramesar

Email address: raj.ramesar@uct.ac.za

 

  1. Cancer pathways analysis in individuals with Lynch Syndrome

Contact UCT investigator: Raj Ramesar

Email address: raj.ramesar@uct.ac.za

 

  1. Can an Enhanced Recovery After Surgery Program Improve patient outcomes after elective colorectal cancer surgery ?

Contact UCT investigator: Ravi Oodit

Email address: ravioodit@gmail.com

 

Gastrointestinal cancer 

  1. A biochemical analysis of mucus and mucins in pseudomyxoma peritonei (cancer of the appendix)

Contact UCT investigator: Anwar Mall

Email address: anwar.mall@uct.ac.za  

 

  1. Characterization of gastrointestinal stromal tumour mutations in a South African cohort

Contact UCT investigator: Barbara Robertson

Email address: barbara.robertson@uct.ac.za

 

  1. A phase 3 randomized double-blind clinical study of pembrolizumab (MK-3475) plus chemotherapy as first-line treatment in participants with HER-2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)

Contact UCT investigator: Barbara Robertson

Email address: barbara.robertson@uct.ac.za

 

 

Gynaecological cancers

A.Cervical cancer

 

  1. Normalization of tumour metabolism to modulate radiation response

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

  1. Role of Seminal fluid on cervical cancer development

Contact UCT investigator: Arieh Katz

Email address: arieh.katz@uct.ac.za

 

  1. The Genetics and management of cervical cancer in Zimbabwe: focusing  on pharmacogenetics

Contact UCT investigator: Collet Dandara

Email address: collet.dandara@uct.ac.za

 

  1. Investigation of the impact of the vaginal microbiota on human papillomavirus infections

Contact UCT investigator: Anna-Lise Williamson

Email address: anna-lise.williamson@uct.ac.za

 

  1. A study of the feasibility of introducing a Swedish HPV test for the management of cervical disease in the Eastern Cape

Contact UCT investigator: Anna-Lise Williamson

Email address: anna-lise.williamson@uct.ac.za

 

  1. Identification and characterization of HPV entry receptors as potential drug targets

Contact UCT investigator: Georgia Schäfer

Email address: georgia.schafer@uct.ac.za

 

  1. The role of cell surface vimentin for HPV16 infection

Contact UCT investigator: Georgia Schäfer

Email address: georgia.schafer@uct.ac.za

 

  1. The role of surfactant proteins in immunity to HPV16 infection

Contact UCT investigator: Georgia Schäfer

Email address: georgia.schafer@uct.ac.za

 

  1. Molecular Markers Predicting CIN3 with high risk to Progress to Cervical Cancer

Contact UCT investigator: Hue-Tsi Wu

Email address: hue-tsi.wu@uct.ac.za

 

  1. Immunohistochemical investigation for invadopodia formation in cervical squamous cell carcinoma

Contact UCT investigator: Hue-Tsi Wu

Email address: hue-tsi.wu@uct.ac.za

 

  1. Primary health care providers knowledge and management of symptoms suggestive of cervical  cancer

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. A discourse analysis of the academic literature about cervical cancer in Africa

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. Regulation of HPV infection and cervical cancer progression following helminth infection

Contact UCT investigator: Katherine Smith

Email address: katie.smith@uct.ac.za

 

  1. Modelling the impact of prevention strategies on cervical cancer incidence in South Africa

Contact UCT investigator: Leigh Johnson

Email address: leigh.johnson@uct.ac.za

 

  1. The Role of MRI in Early Cervical Cancer

Contact UCT investigator: Linda Rogers

Email address: linda.rogers@uct.ac.za

 

  1. Improving the specificity of HPV Screen-and-Treat in South Africa

Contact UCT investigator: Lynette Denny

Email address: lynette.denny@uct.ac.za

 

  1. Therapeutic vaccine against HPV types 16 and 18

Contact UCT investigator: Lynette Denny

Email address: lynette.denny@uct.ac.za

 

  1. Long term outcomes of women treated for HSIL at a university teaching hospital colposcopy unit in South Africa: a 5 year retrospective cohort study.

Contact UCT investigator: Lynette Denny

Email address: lynette.denny@uct.ac.za

 

  1. Audit of indications for and outcomes of cone biopsies performed at GSH colposcopy clinic 

Contact UCT investigator: Lynette Denny

Email address: lynette.denny@uct.ac.za

 

  1. Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. A cross-sectional, combined methods study: women diagnosed with invasive cervical cancer presenting to Groote Schuur Hospital

Contact UCT investigator: Tracey Adams

Email address: tracey.adams@uct.ac.za

 

  1. The impact of positive margins and crypt involvement in Large Loop Excision of the Transformation Zone (LLETZ) on recurrence rate of premalignant disease of the cervix

Contact UCT investigator: Tracey Adams

Email address: tracey.adams@uct.ac.za

 

  1. Investigation of the status and oncogenic function of TBX3 in cervical cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Repurposing of commercial drugs, either alone or in combination to target TBX3 for the treatment of cervical cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

B.Non-site specific gynaecological cancer

 

  1. Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract

Contact UCT investigator: Hue-Tsi Wu

Email address: hue-tsi.wu@uct.ac.za

 

  1. Investigating women’s sexuality post gynaecological cancer treatment at Groote Schuur Hospital

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

C.Ovarian cancer

  1. International ovarian & testicular stromal tumour registry

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract

Contact UCT investigator: Hue-Tsi Wu

Email address: hue-tsi.wu@uct.ac.za

 

  1. Lynch Syndrome

Contact UCT investigator: Paul Goldberg

Email address: paul.goldberg@uct.ac.za

 

  1. Ethnic differences in the genetic and molecular profile of women diagnosed with ovarian cancer

Contact UCT investigator: Tracey Adams

Email address: tracey.adams@uct.ac.za

 

  1. A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First- Line Treatment of BRCA non-mutated Advanced Epithelial Ovarian Cancer (EOC)

Contact UCT investigator: Nazia Fakie

Email address: n.fakie@uct.ac.za

 

 

D.Uterine cancer

  1. Prevalence of Gynaecological disease in Women with an HLM1 Mutation in the Northern Cape Province, South Africa. Study of a population with Lynch Syndrome.

UCT investigator: Nomonde Mbatani

Email address: nomonde.mbatani@uct.ac.za

 

  1. Lynch Syndrome

Contact UCT investigator: Paul Goldberg

Email address: paul.goldberg@uct.ac.za

 

E.Vulvar cancer

 

  1. Sentinel Lymph Node Biopsy for Early Vulval Cancer in a Limited Resource Setting

UCT investigator: Linda Rogers

Email address: linda.rogers@uct.ac.za

 

  1. Prognostic importance of immune cells in vulvar cancer

Contact UCT investigator: Lynette Denny /Rakiya Saidu

Email address: lynette.denny@uct.ac.za / rakiya.saidu@uct.ac.za

 

  1. Vulval cancer review at GSH with emphasis on HPV associated disease

Contact UCT investigator: Tracey Adams

Email address: tracey.adams@uct.ac.za

 

 

Head and neck cancer

  1. Salivary gland rescue to overcome radiotherapy-induced xerostomia

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

Kaposi’s sarcoma

  1. The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa

Contact UCT investigator: Georgia Schäfer

Email address: georgia.schäfer@uct.ac.za

 

  1. Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

  1. Retrospective review of patients with Epidemic Kaposi sarcoma treated between 2010 and 2014 at Groote Schuur Hospital

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

 

Leukaemia

  1. Adapted Treatment Regimens for Hepatoblastoma and AML

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Normalization of tumour metabolism to modulate radiation response

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

  1. Myeloproliferative neoplasms

Contact UCT investigator: Estelle Verburgh

Email address: estelle.verburgh@uct.ac.za

 

Liver cancer

  1. Adapted Treatment Regimens for Hepatoblastoma and AML

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

  1. Palliative drainage of malignant hilar bile duct obstruction in Academic Hospitals in the Western Cape

Contact UCT investigator: Eduard Jonas

Email address: eduard.jonas@uct.ac.za

 

  1. Do Hepatitis B and HIV interact in the aetiology of hepatocellular carcinoma

Contact UCT investigator: Michael Kew

Email address: michael.kew@uct.ac.za

 

Lung cancer

  1. Normalization of tumour metabolism to modulate radiation response

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

  1. Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death

Contact UCT investigator: Alistair Hunter / Michelle Parker

Email address: alistair.hunter@uct.ac.za / michelle.parker@uct.ac.za

 

Lymphoma

  1. Aggressive Lymphoma: diagnostic pathway, treatment and differential diagnosis

Contact UCT investigator: Estelle Verburgh

Email address: estelle.verburgh@uct.ac.za

 

  1. Establishing "best-care" diagnostic pathway for investigation of lymphadenopathy

Contact UCT investigator: Estelle Verburgh / Katherine Antel

Email address: estelle.verburgh@uct.ac.za / katherine.antel@uct.ac.za

 

  1. Hodgkin lymphoma CD 68 prognostic score

Contact UCT investigator: Estelle Verburgh / Katherine Antel

Email address: estelle.verburgh@uct.ac.za / katherine.antel@uct.ac.za

 

  1. Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG)

Contact UCT investigator: Marc Hendricks

Email address: marc.hendricks@uct.ac.za

 

  1. Biomarker identification in HIV and non-HIV related diffuse large B cell lymphomas

Contact UCT investigator: Richard Naidoo

Email address: richard.naidoo@uct.ac.za

 

  1. Investigation of the molecular mechanisms of HIV-induced Burkitt’s lymphoma development

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. The cooperation of EBV and HIV in the development of HIV-associated Burkitt lymphoma.

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. A comparison of B-cell and T-cell populations and activation markers of Diffuse Large B-cell Lymphoma HIV positive and HIV negative cases at Groote Schuur hospital. 

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. The prevalence of MYD88 and CD79B mutations in DLBCL cases referred to Groote Schuur hospital – a retrospective study.

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. The molecular and functional significance of SOCS1 in lymphomagenesis. 

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

  1. A randomized controlled double blind phase III trial to compare the efficacy, safety and pharmacokinetics of GP2013 plus cyclophosphamide, vincristine, prednisone, followed by GP2013 or MabThera Contact UCTtenance therapy in patients with previously untreated, advanced stage follicular lymphoma

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

  1. HIV-associated Muilticentric Castleman's Disease: A Clinical Review of 53 cases presenting to a single institution in South Africa

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

  1. A Randomized, Double-Blind, Multi-center, Multi-national Trial to Evaluate the Efficacy, Safety and Immunogenicity of SAIT101 Versus Rituximab as First-line Immunotherapy Treatment in Patients with Low Tumor Burden Follicular Lymphoma

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

Myeloma

  1. Cancer testis antigens in multiple myeloma

Contact UCT investigator: Karen Shires

Email address: karen.shires@uct.ac.za

 

  1. Mage antigen expression: A tool for malignant cell identification, disease monitoring and determining diseases mechanisms

Contact UCT investigator: Karen Shires

Email address: karen.shires@uct.ac.za

 

Neuroendocrine tumours

  1. Natural history and outcome in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at a single tertiary center

Contact UCT investigator: Eduard Jonas

Email address: eduard.jonas@uct.ac.za

 

  1. A prospective, randomised, Controlled, Open-label, Multicentre phase III study to evaluate efficacy and safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide compared to targeted molecular therapy with Everolimus in patients with inoperable, progressive, somato-statin receptor-positive (SSTR+), neuroendocrine tumours of gastroenteric or pancreatic origin (GEP-NET)

Contact UCT investigator: Barbara Robertson / R Steyn

Email address: barbara.robertson@uct.ac.za

 

Non-site specific cancer

  1. Radiation-induced motility of cancer cells in vitro

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

  1. Conserving the integrity of recombinant immunodiagnostics/-therapeutics by compatible solutes.

Contact UCT investigator: Anathi Nkayi /Stefan Barth

Email address: nkyana001@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. Mitochondrial flux in cell death processes induced by cancer therapy

Contact UCT investigator: Andre Hendrikse          

Email address: andre.hendrikse@uct.ac.za

 

  1. The effect of drug or carcinogen treatment on differential expression of drug metabolism genes in cancer cells

Contact UCT investigator: Collet Dandara            

Email address: collet.dandara@uct.ac.za

 

  1. Development of a cancer survivorship plan for South Africa

Contact UCT investigator: Delva Shamley

Email address: delva.shamley@uct.ac.za

 

  1. Quantifying the interaction of antibody based fusion proteins with primary cell and tissues of African patients

Contact UCT investigator: Dharanidharan Ramamurthy /Stefan Barth

Email address: dharanidharan.ramamurthy@uct.ac.za / stefan.barth@uct.ac.za

 

  1. Adapting CAREX (CARcinogen EXposure) tool for occupational exposures in South Africa

Contact UCT investigator: Hanna-Andrea Rother

Email address: andrea.rother@uct.ac.za

 

  1. A bibliometric analysis of cancer research in South Africa

Contact UCT investigator: Jennifer Moodley

Email address: jennifer.moodley@uct.ac.za

 

  1. Establishment of recombinant antibody technology platforms for the development of diagnostically- and therapeutically-applied fusion proteins

Contact UCT investigator: Krupa Naran /Stefan Barth

Email address: krupa.naran@uct.ac.za / stefan.barth@uct.ac.za

 

  1. Impact of cisplatin-induced hearing loss on health-related quality of life: A prospective cohort study

Contact UCT investigator: Lebogang Ramma

Email address: lebogang.ramma@uct.ac.za

 

  1. Patient preferences & priorities for end-of-life care at Tiyanjane Palliative Care clinic, Blantyre, Malawi

Contact UCT investigator: Linda Ganca

Email address: linda.ganca@uct.ac.za

 

  1. Loss, Grief & bereavement: Experiences of immigrants receiving Palliative Care Services at Met’Impilo Care Centre

Contact UCT investigator: Linda Ganca

Email address: linda.ganca@uct.ac.za

 

  1. Understanding the Dignity Experience and Assessing the Impact of a Modified Dignity Psychotherapy Intervention in Patients with Terminal Illness

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. Investigating how South African oncologist manage depression in late stage cancer patients

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. An evaluation of patients’ palliative care needs and their response to implementation of individualized care plans initiated at a tertiary oncology service

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. A study to explore the factors that influence family caregivers of patients receiving palliative care for island Hospice to seek help at emergency

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. An assessment of the quality of care provided to patients who died in the care of Tshwane district hospital

Contact UCT investigator: Liz Gwyther

Email address: liz.gwyther@uct.ac.za

 

  1. Prevention of chemotherapy induced alopecia with scalp cooling – does hair curl influence outcome?

Contact UCT investigator: Nonhlanhla Khumalo

Email address: nonhlanhla.khumalo@uct.ac.za

 

  1. Generation and evaluation of novel CD64-specific immunodiagnostic and therapeutic tools to selectively eliminate dysregulated macrophages in chronic diseases

Contact UCT investigator: Olusiji Alex Akinrinmade /Stefan Barth

Email address: aknolu025@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. Comparative assessment of different hosts for expression of recombinant immunopharmaceuticals

Contact UCT investigator: Precious Hlongwane / Stefan Barth

Email address: hlnpre001@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. A determination of the prevalence and reasons why palliative care patients present to the Groote Schuur Hospital Emergency Department

Contact UCT investigator: Radha Govender/Rene Krause

Email address: radha@redchilli.co.za / rene.krause@uct.ac.za

 

  1. Investigating the role of genetic variation in OTOS in response to cisplatin induced ototoxicity in South African Cancer patients

Contact UCT investigator: Raj Ramesar

Email address: Raj.ramesar@uct.ac.za

 

  1. The genetics of anthracycline-induced cardiotoxicity in cancer patients 

Contact UCT investigator: Raj Ramesar

Email address: Raj.ramesar@uct.ac.za

 

  1. Identifying patients for Palliative Care in South Africa

Contact UCT investigator: Rene Krause / Liz Gwyther

Email address: rene.krause@uct.ac.za / liz.gwyther@uct.ac.za

 

  1. Development of novel metallodrugs based on platinum group metals for treating cancer

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Opposing roles for the t-box transcription factor, tbx3, in cancer: oncoprotein vs tumour suppressor

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Process optimisation and scale-up for production of immunotherapeutic recombinant fusion proteins

Contact UCT investigator: Sikozile Ncembu /Stefan Barth

Email address: ncmsik001@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. Establishment of Recombinant Antibody Technologies Allowing the Generation of Disease Specific Immunodiagnostics and Therapeutics

Contact UCT investigator: Trishana Nundalall /Stefan Barth

Email address: nndtri001@myuct.ac.za / stefan.barth@uct.ac.za

 

  1. Nuclear Transport Proteins as cancer therapeutic targets

Contact UCT investigator: Virna Leaner

Email address: virna.leaner@uct.ac.za

 

  1. Targeted proteomic approaches to identify novel cancer biomarkers.

Contact UCT investigator: Virna Leaner

Email address: virna.leaner@uct.ac.za

  1. An analysis of oral morphine of oral morphine use at primary health care facilities in the Cape Town Metro

Contact UCT investigator: Rene Krause

Email address: rene.krause@uct.ac.za

 

Oesophageal cancer

 

  1. A phase 3 randomized double-blind clincal study of pembrolizumab (MK-3475) plus chemotherapy as first-line treatment in participants with HER-2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)

Contact UCT investigator: Barbara Robertson

Email address: barbara.robertson@uct.ac.za

 

  1. Patient and tumour characteristics as prognostic factors in oesophageal cancer: survival analysis

Contact UCT investigator: Collet Dandara            

Email address: Collet.dandara@uct.ac.za

 

  1. Hospital based oesophageal cancer registry

Contact UCT investigator: Iqbal Parker

Email address: Iqbal.parker@uct.ac.za

 

  1. Molecular biology and molecular markers of oesphageal cancer

Contact UCT investigator: Iqbal Parker

Email address: Iqbal.parker@uct.ac.za

 

  1. Whole genome sequence analysis of African oesophageal squamous cell carcinoma

Contact UCT investigator: Iqbal Parker

Email address: Iqbal.parker@uct.ac.za

 

  1. The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

Pancreatic cancer

 

  1. Analysis of the expression profile and antigenicity of cancer-testis antigens and of urinary biomarkers in pancreatic adenocarcinoma and chronic pancreatitis

Contact UCT investigator: Eduard Jonas

Email address: eduard.jonas@uct.ac.za

 

  1. A prospective, longitudinal, observational study to assess the health related quality of life of patients with pancreatic adenocarcinoma in South Africa

Contact UCT investigator: Eduard Jonas / Urda Kotze

Email address: eduard.jonas@uct.ac.za / urda.kotze@uct.ac.za

 

  1. A systematic review and meta-analysis to assess the equivalence of survival of patients with borderline resectable and unresectable locally advanced pancreatic ductal adenocarcinoma

Contact UCT investigator: Eduard Jonas

Email address: eduard.jonas@uct.ac.za

 

  1. Palliative care audit on pancreatic adenocarcinoma cancer patients in Groote Schuur hospital

Contact UCT investigator: Rene Krause

Email address: rene.krause@uct.ac.za

Prostate cancer

  1. The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer

Contact UCT investigator: Shaheen Mowla

Email address: shaheen.mowla@uct.ac.za

 

 

 

Salivary gland

  1. Salivary gland rescue to overcome radiotherapy-induced xerostomia

Contact UCT investigator: Alistair Hunter

Email address: alistair.hunter@uct.ac.za

 

Sarcoma

  1. The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa

Contact UCT investigator: Georgia Schäfer

Email address: georgia.schafer@uct.ac.za

 

  1. A randomized controlled study of yondelis (trabectedin) or dacarbazine for the treatment of advanced liposarcoma or leiomyosarcoma 

Contact UCT investigator: Jeanette Parkes

Email address: jeanette.parkes@uct.ac.za

 

  1. Identification of molecular mechanisms regulating the tumour suppressor role of TBX3 in fibrosarcoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Overexpression of the T-box transcription factor, TBX3, as an early marker of sarcomas              

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Investigating novel drugs and drug targets for the treatment of rhabdomyosarcoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

  1. Retrospective review of patients with Epidemic Kaposi sarcoma treated between 2010 and 2014 at Groote Schuur Hospital

Contact UCT investigator: Zainab Mohamed

Email address: zainab.mohamed@uct.ac.za

 

  1. C-myc, TBX3 and nucleolin as combination biomarkers for the reliable diagnosis of several sarcoma subtypes

Contact UCT investigator: Sharon Prince/ Dhiren Govender/ Jeannette Parkes/ Komala Pillay

Email address: sharon.prince@uct.ac.za

 

  1. The role of the oncogenic TBX3 and nucleolin in the malignant transformation of mesenchymal stem/stromal cells into sarcoma subtypes

Contact UCT investigator: Sharon Prince/ Jeannette Parkes/ Komala Pillay

Email address: sharon.prince@uct.ac.za

 

  1. Marine-derived chromomycin A5: a novel strategy to treat TBX2-driven rhabdomyosarcoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

Skin cancer

 

  1. Proteomic studies on patient responses to vaccination and chemotherapy/ radiotherapy in melanoma          

Contact UCT investigator: Jonathan Blackburn

Email address:Jonathan.blackburn@uct.ac.za

 

  1. Identification of novel drugs and drug targets for treating melanoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. An investigation of the phenotypic switching of dermal fibroblasts to cancer associated fibroblasts in the melanoma tumour microenvironment

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

  1. Evaluation of tumour associated antigens to optically label cutaneous basal cell carcinoma for surgical excision

Contact UCT investigator: Stefan Barth / Nonhlanhla Khumalo

Email address: stefan.barth@uct.ac.za / n.khumalo@uct.ac.za

 

  1. The role and regulation of TBX2/TBX3 in melanoma

Contact UCT investigator: Sharon Prince

Email address: sharon.prince@uct.ac.za

 

Spinal cancer

  1. Review of surgical management primary spine tumours in adult and paediatric population

Contact UCT investigator: Robert Dunn

Email address:Robert.dunn@uct.ac.za

 

Testicular cancer

  1. International Ovarian & Testicular Stromal Tumour Registry

Contact UCT investigator: Alan Davidson             

Email address: alan.davidson@uct.ac.za

 

Thyroid cancer

  1. Genetics of thyroid carcinoma to develop cost-effective management     

Contact UCT investigators:  Ian Ross / Collet Dandara     

Email address: Ian.ross@uct.ac.za / Collet.dandara@uct.ac.za

 

Urogenital cancer

  1. Lynch Syndrome

Contact UCT investigator: Paul Goldberg

Email address: paul.goldberg@uct.ac.za

 

 

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