2018 Cancer Projects

Cancer Projects

Type of Cancer

Anal Lung
Bladder Lymphoma
Bone Myeloma
Brain Neuroblastoma
Breast  Neuroendocrine tumours
Childhood Non site-specific
Colorectal Oesophageal
Gastrointestinal Pancreatic

Gynaecological

A. Cervical

B. Non site-specific gynaecological

C. Ovarian

D Uterine

E. Vulvar

Prostate

Salivary gland

Sarcoma

Skin

Spinal

Testicular

Head and neck  Thyroid
Leukaemia Urogenital
Liver  

 

  UCT Investigator
Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus

Dhiren Govender

  UCT Investigator

A phase 3 randomized, controlled clinical trial of Pembrolizumab (MK-3475) with or without platinum chemotherapy vs chemotherapy in subjects with advanced or metastatic urothelial carcinoma: Protocol# MK3475-361

David Anderson

Does enhanced recovery after surgery for radical cystectomy improve outcomes?

Justin Howlett

  UCT Investigator

Medical image synthesis - Development and validation of MRI-based synthetic CT: applications in treating bone pathologies

Tinashe Mutsvangwa

  UCT Investigator

Paediatric brain tumours in South Africa

Anthony Figaji

Medulloblastoma Jeanette Parkes
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma Sharon Prince
 

UCT Investigator

Identification of novel drug targets for treating breast cancer Sharon Prince
Pathways to breast cancer presentation Jennifer Moodley
The genetics of anthracycline-induced cardiotoxicity in breast cancer patients Horacia Naidoo
Triple negative breast cancer : tumour-initiating cells and tailoring therapy Horacia Naidoo
A correlation between shoulder pain and dysfunction and inflammatory cytokine genotyping in breast cancer patients Delva Shamley
Prevalence of upper limb morbidity following adjuvant therapy in breast cancer survivors in SA Delva Shamley
Pain lateralisation in breast cancer patients: a fMRI and genotyping study Delva Shamley
Opioid prescription post-surgery for breast cancer and the development of chronic pain Delva Shamley
Development and implementation of an integrated  lymphoedema management pathway following treatment for breast cancer Delva Shamley
A randomised, Double blind, Phase 3 study evaluating the efficacy and safety of ABP 980 compared with Trastuzumab in subjects with HER2 positive early breast cancer  David Anderson
Testing a dual-modality system that combines full-field digital mammography and automated breast ultrasound for the detection of breast cancer Tania Douglas / Kit Vaughan
Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa Jennifer Moodley

Extended Cost Effectiveness of Interventions for Early Detection & Treatment of Breast Cancer: A Case Study of South Africa and Uganda

Edina Sinanovic

Contraceptive needs and fertility intentions of women with breast cancer in Cape Town

Jane Harries
System delays in symptomatic breast cancer diagnosis in South Africa Jennifer Moodley

Primary health care providers knowledge and management of symptoms suggestive of breast cancer

Jennifer Moodley
Impact of chemotherapy-induced alopecia

Nonhlanhla Khumalo

Clinical Trial of the Aceso Dual-Modality System for the Early Detection of Breast Cancer: A Joint Project Between Number Two Military Hospital In Wynberg and CapeRay Medical (Pty) Ltd

Kamila Padia / Kit Vaughan

Human Dendritic Cell Vaccination (DCV) Against Breast cancer: A Single Blind randomized trial

Keertan Dheda / David Anderson

Chemoresistance and metastasis in oesophageal and breast cancer -using multicellular tumour spheroids as a model

Kevin Dzobo

Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity Sharon Prince
The repurposing of anti-malarial compounds for anti-cancer activity with a special focus on breast cancer Sharon Prince / Kelly Chibale
The anti-cancer activity of extracts derived from millets and kraalbos Sharon Prince / Anwar Jardine / Suparna Chakraborty
A Proof of Principle Application of the GlycoEnzyme Gene Biomarker for Early Detection of Breast Cancer in a South African Population Kevin Naidoo
Quality of Life after Breast Reconstruction Lydia Cairncross
Radio Guided Occult Lesion Localisation as a diagnostic and therapeutic procedure: Clinical review at a single South African institution Lydia Cairncross
Establishment of technology platforms in support of future precision medicine applications in South Africa Musa Mhlanga / Stefan Barth
A randomized open label phase III study of single agent pembrolizumab versus single agent chemotherapy per physician’s choice for metastatic triple negative breast cancer (mTNBC) Zainab Mohamed
An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria Liz Gwyther
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
Chloroquine as a modulator of autophagy and radiation response Alistair Hunter / Andre Hendrikse
Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death Alistair Hunter / Michelle Parker
Lynch Syndrome Paul Goldberg
  UCT Investigator
B-cell lymphoma at the Red Cross Children’s Hospital in the HIV era Alan Davidson
HIV and childhood malignancy in South Africa
Prevalence, incidence and risk factors, survival and prognosis for HIV-infected children developing cancer
Factors Associated with Childhood Tumours (FACT) study
Childhood histiocytosis in South African paediatric oncology units
Low grade gliomas treated at the UCT Academic Hospital Complex 2001-2013
Paediatric brain tumours in South Africa Anthony Figaji
Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG) Marc Hendricks
Clinical outcome of children with Hodgkin Lymphoma after chemotherapy alone – the Red Cross Children’s Hospital experience Alan Davidson
National incidence and treatment outcomes of paediatric acute lymphoblastic leukaemia in South Africa over a five year period
Race as a prognostic determinant in children with acute lymphoblastic leukaemia    
The results of acute myeloid leukaemia treated with RCCH Rx2071 (adapted from the MRC AML 15 protocol)    
Adapted Treatment Regimens for Hepatoblastoma and AML
International ovarian & testicular stromal tumour registry
Use of palliative chemotherapy in South Africa: National survey of paediatric oncologists and experience in a single unit Michelle Meiring
Palliative & supportive care needs of children with cancer from the family’s viewpoint: Can we do better? Michelle Meiring
Epidemiology of paediatric Cancer in the RCCH/GSH/UCT complex Jennifer Moodley / Alan Davidson / Jeannette Parkes / Komala Pillay
  UCT Investigator
Dysregulation of CT antigen expression in HNPCC and microbially-associated colorectal cancers Jonathan Blackburn
Pharmacoproteomic and pharmacogenomic profiling of stage II and III primary colorectal carcinoma tissue
Cancer pathways analysis in individuals with Lynch Syndrome Raj Ramesar
A genetic registry for colorectal cancers Raj Ramesar

Establishment of technology platforms in support of future precision medicine applications in South Africa

Musa Mhlanga / Stefan Barth
Worm power: Can helminths modify the development of colorectal cancer? Katie Smith
Cancer Cell Behaviour Following Parasite Exposure Katie Smith
Phase III study of Pembrolizumab vs Chemo in microsatellite instability-high or mismatch repair deficient Stage 4 Colorectal CA

Lucinda Shepherd

A comparative cost analysis of two screening strategies for colorectal cancer in Lynch Syndrome in a tertiary hospital, South Africa Edina Sinanovic

Lynch Syndrome

Paul Goldberg

Can an Enhanced Recovery After Surgery Program Improve patient outcomes after elective colorectal cancer surgery ?

Ravi Oodit

  UCT Investigator
Characterization of gastrointestinal stromal tumour mutations in a South African cohort Barbara Robertson
MK-3475-062: A randomised active-controlled, partially blinded, biomarker select, phase III clinical trial of pembrolizumab as monotherapy and in combination with cisplatin + 5-fluorourcil versus placebo + cisplatin and 5-fluorouracil as first-line treatment in subjects with advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma Barbara Robertson
MK-3475-061-00: A phase III, randomized open-label clinical trial of pembrolizumab (MK-3475) versus paclitaxel in subjects with recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma who progressed after first-line therapy with platinum and fluoropyrimidine Barbara Robertson
A biochemical analysis of mucus and mucins in pseudomyxoma peritonei (cancer of the appendix) Anwar Mall

First line treatment in patients with advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma

Barbara Robertson
  UCT Investigator
Preventing cervical cancer: Using mobile technology to improve management and follow-up of clients

Jennifer Moodley

Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa Jennifer Moodley
Audit of indications for and outcomes of cone biopsies performed at GSH colposcopy clinic  Lynette Denny
Therapeutic vaccine against HPV types 16 and 18 Lynette Denny
Improving the specificity of HPV Screen-and-Treat in South Africa Lynette Denny
The cellular mechanisms induced by photodynamic therapy in carcinomas of the skin and cervix Lester Davids
Identification and characterization of HPV entry receptors as potential drug targets Georgia Schafer
Investigation of the impact of the vaginal microbiota on human papillomavirus infections Anna-Lise Williamson
A study of the feasibility of introducing a Swedish HPV test for the management of cervical disease in the Eastern Cape Anna-Lise Williamson
The role of cell surface vimentin for HPV16 infection Georgia Schafer
The role of surfactant proteins in immunity to HPV16 infection Georgia Schafer

Molecular landscape of cervical cancer development

Hu-Tsi Wu
Immunohistochemical investigation for invadopodia formation in cervical squamous cell carcinoma Hu-Tsi Wu
Primary health care providers knowledge and management of symptoms suggestive of cervical  cancer Jennifer Moodley
Cancer Cell Behaviour Following Parasite Exposure Katie Smith
Modelling the impact of prevention strategies on cervical cancer incidence in South Africa Leigh Johnson
The Role of MRI in Early Cervical Cancer Linda Rogers
Long term outcomes of women treated for HSIL at a university teaching hospital colposcopy unit in South Africa: a 5 year retrospective cohort study Lynette Denny
Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity Sharon Prince
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
The Genetics and management of cervical cancer in Zimbabwe: focusing  on pharmacogenetics Collet Dandara

Role of Seminal fluid on cervical cancer development

Arieh Katz
A cross-sectional, combined methods study: women diagnosed with invasive cervical cancer presenting to Groote Schuur Hospital Tracey Adams
The impact of positive margins and crypt involvement in Large Loop Excision of the Transformation Zone (LLETZ) on recurrence rate of premalignant disease of the cervix Tracey Adams
  UCT Investigator
Investigating women’s sexuality post gynaecological cancer treatment at Groote Schuur Hospital Jennifer Moodley
Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract Hu-Tsi Wu
An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria Liz Gwyther
  UCT Investigator

International ovarian & testicular stromal tumour registry

Alan Davidson
Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract Hu-Tsi Wu
Ethnic differences in the genetic and molecular profile of women diagnosed with ovarian cancer Tracey Adams
Lynch Syndrome Paul Goldberg
  UCT Investigator
Prevalence of Gynaecological disease in Women with an HLM1 Mutation in the Northern Cape Province, South Africa. Study of a population with Lynch Syndrome Nomonde Mbatani
Lynch Syndrome Paul Goldberg
  UCT Investigator
Sentinel Lymph Node Biopsy for Early Vulval Cancer in a Limited Resource Setting Linda Rogers
Prognostic importance of immune cells in vulvar cancer

Lynette Denny / Rakiya Saidu

Vulval cancer review at GSH with emphasis on HPV associated disease

Tracey Adams
  UCT Investigator
Salivary gland rescue to overcome radiotherapy-induced xerostomia Alistair Hunter
  UCT Investigator
Myeloproliferative neoplasms Estelle Verburgh
Adapted Treatment Regimens for Hepatoblastoma and AML Alan Davidson
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
  UCT Investigator
Do Hepatitis B and HIV interact in the aetiology of hepatocellular carcinoma Michael Kew
HIV-associated hepatocellular carcinoma – prevalence, presentation, survival and risks Barbara Robertson
Adapted Treatment Regimens for Hepatoblastoma and AML Alan Davidson
  UCT Investigator
A Randomised, Open Label, Phase III Study of Overall Survival Comparing Pembrolizumab (MK-3475) versus Platinum Based Chemotherapy in Treatment Naïve Subjects with PD-L1 Positive advanced or Metastatic Non-Small Cell Lung Cancer Lucinda Shepherd
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
Chloroquine as a modulator of autophagy and radiation response Alistair Hunter / Andre Hendrikse

Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death

Alistair Hunter / Michelle Parker
  UCT Investigator
Investigation of the molecular mechanisms of HIV-induced Burkitt’s lymphoma development Shaheen Mowla
Expression and function of miRNA in HIV-associated lymphomas
A randomized controlled double blind phase III trial to compare the efficacy, safety and pharmacokinetics of GP2013 plus cyclophosphamide, vincristine, prednisone, followed by GP2013 or MabThera Contact UCTtenance therapy in patients with previously untreated, advanced stage follicular lymphoma Zainab Mohamed
Biomarker identification in HIV- and non HIV related diffuse large B cell lymphomas Richard Naidoo
Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG) Marc Hendricks

The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer

Shaheen Mowla
Aggressive Lymphoma: diagnostic pathway, treatment and differential diagnosis Estelle Verburgh

Establishing "best-care" diagnostic pathway for investigation of lymphadenopathy

Estelle Verburgh / Katherine Antel

Hodgkin lymphoma CD 68 prognostic score

Estelle Verburgh / Katherine Antel
HIV-associated Muilticentric Castleman's Disease: A Clinical Review of 53 cases presenting to a single institution in South Africa Zainab Mohamed

A Randomized, Double-Blind, Multi-center, Multi-national Trial to Evaluate the Efficacy, Safety and Immunogenicity of SAIT101 Versus Rituximab as First-line Immunotherapy Treatment in Patients with Low Tumor Burden Follicular Lymphoma

Zainab Mohamed
  UCT Investigator
Cancer testis antigens in multiple myeloma Karen Shires
Mage antigen expression: A tool for malignant cell identification, disease monitoring and determining diseases mechanisms
  UCT Investigator
Photodynamic therapy as a potential treatment modality in neuroblastoma cancers Lester Davids
  UCT Investigator
Natural history and outcome in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at a single tertiary center Eduard Jonas
  UCT Investigator
Mitochondrial flux in cell death processes induced by cancer therapy Andre Hendrikse
The role of the DNA-editing enzyme, activation-induced cytidine deaminase (AID), in cancer Shaheen Mowla
The effect of drug or carcinogen treatment on differential expression of drug metabolism genes in cancer cells Collet Dandara
Opposing roles for the t-box transcription factor, tbx3, in cancer: oncoprotein vs tumour suppressor Sharon Prince
Development of novel metallodrugs based on platinum group metals for treating cancer Sharon Prince
Investigating the role of genetic variation in OTOS in response to cisplatin induced ototoxicity in South African Cancer patients Raj Ramesar
The genetics of anthracycline-induced cardiotoxicity in cancer patients Raj Ramesar
Radiation-induced autophagy in cancer cells in vitro Alistair Hunter
Radiation-induced motility of cancer cells in vitro Alistair Hunter
Normalization of tumour metabolism to modulate radiation response Alistair Hunter
Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death Alistair Hunter / Michelle Parker
Development of an ajoene-based anti-cancer therapeutic Catherine Kaschula
Studies into the anti-inflammatory activity of natural products in cancer prevention Catherine Kaschula
A bibliometric analysis of cancer research in South Africa

Jennifer Moodley

Chloroquine as a modulator of autophagy and radiation response Alistair Hunter / Andre Hendrikse
Prevention of chemotherapy induced alopecia with scalp cooling – does hair curl influence outcome? Nonhlanhla Khumalo
Impact of cisplatin-induced hearing loss on health-related quality of life: A prospective cohort study Lebogang Ramma
An evaluation of Palliative care training in oncology registrar training program Rene Krause / Liz Gwyther / David Anderson

Development of a cancer survivorship plan for South Africa

Delva Shamley

Adapting CAREX (CARcinogen EXposure) tool for occupational exposures in South Africa

Hanna-Andrea Rother

Patient preferences & priorities for end-of-life care at Tiyanjane Palliative Care clinic, Blantyre, Malawi

Linda Ganca

Loss, Grief & bereavement: Experiences of immigrants receiving Palliative Care Services at Met’Impilo Care Centre

Linda Ganca

Understanding the Dignity Experience and Assessing the Impact of a Modified Dignity Psychotherapy Intervention in Patients with Terminal Illness

Liz Gwyther
Investigating how South African oncologist manage depression in late stage cancer patients Liz Gwyther
An evaluation of patients’ palliative care needs and their response to implementation of individualized care plans initiated at a tertiary oncology service Liz Gwyther
A study to explore the factors that influence family caregivers of patients receiving palliative care for island Hospice to seek help at emergency Liz Gwyther
An assessment of the quality of care provided to patients who died in the care of Tshwane district hospital Liz Gwyther

The use of traditional herbal medicines among palliative care patients at Mulanje Mission Hospital in Malawi

Rene Krause
Nuclear Transport Proteins as cancer therapeutic targets Virna Leaner
Targeted proteomic approaches to identify novel cancer biomarkers Virna Leaner
  UCT Investigator
Hospital based oesophageal cancer registry Iqbal Parker
Molecular biology and molecular markers of oesphageal cancer Iqbal Parker
Patient and tumour characteristics as prognostic factors in oesophageal cancer: survival analysis Collet Dandara
Whole genome sequence analysis of African oesophageal squamous cell carcinoma  Iqbal Parker
The role of tumour microenvironment components in the development of chemoresistance in oesophageal squamous cell carcinoma Kevin Dzobo
Characterisation of cancer stem cells in human oesophageal squamous cell carcinoma Kevin Dzobo
Chemoresistance and metastasis in oesophageal and breast cancer -using multicellular tumour spheroids as a model Kevin Dzobo

The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer

Shaheen Mowla
  UCT Investigator
Analysis of the expression profile and antigenicity of cancer-testis antigens and of urinary biomarkers in pancreatic adenocarcinoma and chronic pancreatitis Eduard Jonas
A prospective, longitudinal, observational study to assess the health related quality of life of patients with pancreatic adenocarcinoma in South Africa Eduard Jonas / Urda Kotze
  UCT Investigator
The immuno expression of p53-cofactor JMY in prostatic adeno-carcinoma & its effects on cells cycle and Cell Adhesion molecules Dhiren Govender
The Ironman Project: prostate cancer outcomes: an international registry to improve outcomes in men with advanced prostate cancer Ian Davis
Genetic epidemiology of prostate cancer in Africa (MADCAP) Timothy Rebbeck
The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer Shaheen Mowla
  UCT Investigator
Salivary gland rescue to overcome radiotherapy-induced xerostomia Alistair Hunter
  UCT Investigator
Overexpression of the t-box transcription factor, tbx3, as an early marker of sarcomas     Sharon Prince 
A randomized controlled study of yondelis (trabectedin) or dacarbazine for the treatment of advanced liposarcoma or leiomyosarcoma Jeanette Parkes
Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review Zainab Mohamed
The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa Georgia Shafer
The contribution of KSHV to mortality of HIV patients with suspected TB diagnoses in South Africa Georgia Shafer
Investigating novel drugs and drug targets for the treatment of rhabdomyosarcoma Sharon Prince
Identification of molecular mechanisms regulating the tumour suppressor role of TBX3 in fibrosarcoma  Sharon Prince
Retrospective review of patients with Epidemic Kaposi sarcoma treated between 2010 and 2014 at Groote Schuur Hospital Zainab Mohamed
  UCT Investigator
The use of hypericin-induced photodynamic therapy (PDT) as a potential novel adjuvant  cancer therapy Lester Davids
The cellular mechanisms induced by PDT in carcinomas of the skin and cervix 
Proteomic studies on patient responses to vaccination and chemotherapy/ radiotherapy in melanoma Jonathan Blackburn
The use of hypericin-induced photodynamic therapy (PDT) as a potential novel adjuvant  cancer therapy Lester Davids
An investigation into the sensitizing effect of photodynamic therapy in melanoma chemotherapy resistant populations Lester Davids
Investigating Cancer-associated fibroblasts in the Melanoma tumor microenvironment Lester Davids
Identification of novel drugs and drug targets for treating melanoma Sharon Prince
Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity Sharon Prince
Investigating photodynamic therapy as an effective anti-cancer therapy Stefan Barth
Evaluation of tumour associated antigens to optically label cutaneous basal cell carcinoma for surgical excision Stefan Barth / Nonhlanhla Khumalo
  UCT Investigator
Review of surgical management primary spine tumours in adult and paediatric population Robert Dunn
  UCT Investigator
International Ovarian & Testicular Stromal Tumour Registry Alan Davidson    
  UCT Investigator
Genetics of thyroid carcinoma to develop cost-effective management Ian Ross / Collet Dandara
  UCT Investigator
Lynch Syndrome Paul Goldberg

 

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